Abstract
Function of small-fiber assessed with contact heat evoked potentials in patients with diabetic neuropathy
Highlights
Diabetic neuropathy (DN) can affect the nervous system and is one of the most common complications of diabetes mellitus (DM) [1]
Neurofibrillary damage can be the initial symptom of DM [2], which can be seen at the stage of impaired glucose tolerance (IGT)
Our aim was to assess the feasibility of contact heat evoked potentials (CHEPs) for detection diabetic neuropathy (DN) at early stage and analyze the characteristics of smallfiber injury in both of the cranial nerves and spinal nerves
Summary
Diabetic neuropathy (DN) can affect the nervous system and is one of the most common complications of diabetes mellitus (DM) [1]. The Toronto Scoring System (TCSS), a standard method for detecting and monitoring DN [5], mainly evaluates the neurological damage of patients according to clinical manifestations and physical examination. The sympathetic skin response (SSR) can reflect the function of unmyelinated C fibers after sympathetic joints and detect autonomic neuropathy in patients with DM at early stages [7]. Recent research have evaluated the Aδ fibers function of the spinal nerve using the contact heat evoked potentials (CHEPs) [1,8,9]. We evaluated sensitivity of contact heat evoked potentials (CHEPs) compared with sympathetic skin response (SSR) and Toronto Clinical Scoring System (TCSS) in diabetic neuropathy (DN) at early stage and analyze the characteristics of small fibers injury
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