Application of electrophysiological test in prediabetic peripheral neuropathy

Abstract

Early diagnosis of prediabetic peripheral neuropathy depends on the evaluation of small fibers. Traditional nerve conduction tests can only evaluate the function of large myelinated fibers, while lack of sensitivity to small fibrous lesions. These lesions were related to pain and autonomic neuropathy. In recent years, with the progress of neurophysiological diagnosis technology, the early diagnosis of diabetic peripheral neuropathy has been improved. Clinical methods, commonly used in the detection of small fibrous lesions, mainly include skin sympathetic response, quantitative sensory test, contact heat pain evoked potential, and quantitative sudomotor axonal reflex test. In this paper, the pathogenesis of diabetic peripheral neuropathy, neurological pathological changes and applications of electrophysiology technology were reviewed to provide an objective basis for early diagnosis of prediabetic peripheral neuropathy. Key words: Electrophysiological test; Prediabetes; Peripheral neuropathy