Abstract
Several testing procedures are available for assessing cognitive, sensory, and motor functions in animal models. These range from screening tests or batteries to very sophisticated and detailed assessment of functional abilities of the subject. Many of the same cognitive domains can be investigated in animals as those that have been found sensitive to toxicant exposure in children: learning, memory, adaptability, attention, impulsivity, distractibility, and perseverative behavior. Motor function can be assessed in animal models by numerous techniques, and results are directly applicable to humans. The visual system of typical animal models (nocturnal rodents) lacks good color and spatial vision; therefore, important aspects of human vision are difficult to assess. However, visual loss in rodents may be predictive of loss in the same function in humans, and mechanisms of toxicity can be productively studied in rodents. For senses other than vision, the physiological processes of animals and humans are the same or, at least, very similar. It is important to be cognizant of certain caveats. Simple (screening) tests may be nonspecific, insensitive, or both). The lack of good stimulus control for the sensory system assessment results in increased variability and therefore decreased sensitivity.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call