Abstract
Fatigue is one of the most common and debilitating symptoms affecting 75–90% of individuals with multiple sclerosis (MS), significantly impacting their quality of life. This study aimed to assess the prevalence, effects, and risk factors of fatigue among MS patients in Quetta, Pakistan. A cross-sectional descriptive design involved 34 participants aged 20–50 years from Bolan Medical Complex Hospital and nearby facilities. The Fatigue Severity Scale(FSS) was used to evaluate the impact of fatigue on functionality and well-being. Findings revealed that 11 patients experienced severe fatigue due to lack of exercise, and 8 linked it to depression. MRI showed lesions in 4 out of 5 patients with severe fatigue. Additionally, 71% reported worsening of other symptoms due to fatigue. The study highlights fatigue in MS as a complex issue requiring integrated management strategies and contributes to addressing gaps in literature to improve healthcare policies and patient quality of life.
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