Free-Breathing Respiratory Triggered High-Pitch Lung CT: Insights From Phantom and Patient Scans.

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Respiratory motion can affect image quality and thus affect the diagnostic accuracy of CT images by masking or mimicking relevant lung pathologies. CT examinations are often performed during deep inspiration and breath-hold to achieve optimal image quality. However, this can be challenging for certain patient groups, such as children, the elderly, or sedated patients. The study aimed to validate a dedicated triggering algorithm for initiating respiratory-triggered high-pitch computed tomography (RT-HPCT) scans in end inspiration and end expiration in complex and irregular respiratory patterns using an anthropomorphic dynamic chest phantom. Additionally, a patient study was conducted to compare the image quality and lung expansion between RT-HPCT and standard HPCT. The study utilized an algorithm that processes the patient's breathing motion in real-time to determine the appropriate time to initiate a scan. This algorithm was tested on a dynamic, tissue-equivalent chest motion phantom to replicate and simulate 3-dimensional target motion using 28 breathing motion patterns taken from patient with irregular breathing. To evaluate the performance on human patients, prospective RT-HPCT was performed in 18 free-breathing patients. As a reference, unenhanced HPCT of the chest was performed in 20 patients without respiratory triggering during free-breathing. The mean CTDI was 1.73 mGy ± 0.1 mGy for HPCT and 1.68 mGy ± 0.1 mGy for RT-HPCT. For phantom tests, the deviation from the target position of the phantom inlay is known. Image quality is approximated by evaluating stationary versus moving acquisitions. For patient scans, respiratory motion artifacts and inspiration depth were analyzed using expert knowledge of lung anatomy and automated lung volume estimation. Statistical analysis was performed to compare image quality and lung volumes between conventional HPCT and RT-HPCT. In phantom scans, the average deviation from the desired excursion phase was 1.6 mm ± 4.7 mm or 15% ± 24% of the phantom movement range. In patients, the overall image quality significantly improved with respiratory triggering compared with conventional HPCT (P < 0.001). Quantitative average lung volume was 4.0 L ± 1.1 L in the RT group and 3.6 L ± 1.0 L in the control group. This study demonstrated the feasibility of using a patient-adaptive respiratory triggering algorithm for high-pitch lung CT in both phantom and patients. Respiratory-triggered high-pitch CT scanning significantly reduces breathing artifacts compared with conventional nontriggered free-breathing scans.