Abstract
Free radicals are well known for playing a dual role in our body- deleterious as well as beneficial. It includes a metabolic pathway for its generation. Oxidative stress in our body occurs due to excessive generation of free radicals and reduced level of antioxidants, but at low concentrations, these radicals help to perform normal physiological functions of the body. Scientific evidence suggests that antioxidants reduce the risk for chronic diseases including cancer and heart disease. This review shows current tendency in the pyrimidine synthesis and reveals the pyrimidine core to be a very potent moiety which can be a rich source for the synthesis of new compounds having desirable antioxidant activity.
Highlights
Free radicals can be defined as the atoms, molecules, or ions with unpaired electrons in an open shell configuration
The present review is concentrating on the synthesis and antioxidant activity of the pyrimidine nucleus
Pyrimidine is a unique molecule that is associated with several other biological activities
Summary
Free radicals can be defined as the atoms, molecules, or ions with unpaired electrons in an open shell configuration. Development of free radicals in the body is believed to involve in the development of various degenerative diseases; huge generation of free radicals reactive oxygen species and their high activity may lead to progression of a number of pathological disturbances such as inflammation, atherosclerosis, cancer, Parkinson's disease, and Alzheimer's disease. This phenomenon of excessive production of free radicals is termed as oxidative stress. Oxidative properties of oxygen play a vital role in diverse biological systems It includes the following: Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, memory loss, and depression. Cardiovascular diseases such as atherosclerosis, ischemic heart disease, cardiac hypertrophy, hypertension, shock, and trauma
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