Abstract
ACCORDING to present concepts the diversity of antibodies is determined by a similar diversity of the precursors of antibody-producing cells. The existence of a diversified cell population in the lymphoid organs was most directly demonstrated by specific adherence of antigen-reactive cells on antigen columns. Antigen-binding cells were specifically eliminated from lymphoid cell populations of both preimmunized1,2 and non-immunized donors3–5. The non-bound cells were incapable of producing antibody to the antigen applied on the column, yet they could produce antibody to non-related antigens. Plaque forming cell precursors, plaque forming cells and memory cells towards various antigens were separated1–5. In all these cases the cells which specifically adhered to the antigenic column were most probably bone marrow-derived lymphocytes (B cells). On the other hand, no such specific adherence was achieved with thymus-derived lymphocytes (T cells), such as those involved in carrier recognition during immunization with hapten carrier conjugates6 and in cell-mediated immunity.
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