Fractional CO2 Laser with Platelet-Rich Plasma Versus Fractional CO2 Laser with Topical Insulin in The Treatment of Postacne Atrophic Scars

Abstract

Background: Postacne atrophic scars (PAS) are a common acne consequence. When paired with a fractional CO2 laser, topical insulin and PRP may both help. Objective: To compare the effectiveness of a fractional CO2 laser plus PRP versus a fractional CO2 laser with TI in the management of PAS. Methods: This research was conducted on 20 patients suffering from PA atrophic scars. Enrolled patients received four sessions of FCL plus topical PRP in addition to FCL+ topical insulin on left as well as right sides of the face, respectively, at monthly intervals. One month following the fourth session, the last assessment was completed. Side effects were recorded. Patients were encouraged to use photoprotective precautions. Results: There was a statistically significant difference of acne scar grade post treatment between right and left side. Higher improvement is detected among right side treatment than left side. There was a statistically considerable difference between studied groups regarding improvement degree between both sides. For right side 10% excellent improvement, 65% good and 25% fair improvement versus 75% fair improvement and 25% good improvement for left side (P=0.001*). Conclusions: In PAS of skin-of-color populations, TI and PRP coupled with Fractional CO2 laser may both provide improvement with an excellent safety profile. However, the ease of access, low cost, and noninvasive characteristics of TI make it preferable to PRP. The degree of improvement was statistically considerably greater with TI than with PRP (P=0.001*).