Abstract
This study aimed to evaluate the quality and antimicrobial activity of soaps and ointments enriched with aqueous ethanol extracts from barks of Ziziphus mauritiana and Ziziphus mucronata. The galenic formulation allowed the development of ointments as well as soap based on aqueous ethanol extract (70%, v/v) using some excipients. The consistency of the ointments was slightly hard but softens immediately on contact with the skin. The preparation method allowed to get a very good homogeneity with a regular distribution of the extracts. The ointments were stable and no changes on the surface was observed. The ointments were found slight acidic, with pH values varying from 5 to 5.59. It was noticed that enriched soaps displayed neutral pH values neutral varying from 7.28 to 7.49. Moreover, the soap enriched with Z. mauritiana (84%) was more foaming in saline environment than that enriched with Z. mucronata (61.53%). Both bark extract-enriched ointments and soaps displayed excellent antimicrobial activity against fungi and bacteria found on the skin and hands.
Highlights
Dandruff and skin have a protective function against external aggression
The current study aims to evaluate the quality and biological activity of ointment and soap enriched with aqueous ethanol extract from barks of Ziziphus mauritiana and Ziziphus mucronata, in accordance with the logic of contributing to the search for new alternatives to alleviate the cost problems of commercially available antimicrobials while enhancing traditional medicine
The addition of vitamin E may explain this stability, because vitamin E prevents the oxidation of fats. These results were different from those obtained by Yapi et al [17]. These authors observed a slight change with the ointment enriched with aqueous ethanol extract of Aspilia africana (Pers.) C.D
Summary
Dandruff (hair, nails) and skin have a protective function against external aggression These parts of the human body are subject to diseases which can be grouped into two main groups: bacterial and fungal infections. The infections are: Candida intertrigo, Candida perionyxis and onyxis and chronic mucocutaneous candidiasis [3] To treat these infections, antibiotics and antifungals are used. Since the 1940s, antimicrobials (antibiotics, antivirals, antifungals and antiparasitics) have greatly reduced mortality from infectious diseases. These products are not available to everyone, and many people continue to face the scarcity of drugs in the public sector, forcing them to turn to the private sector, where prices can be substantially higher. The price for cheaper generics drugs was on average five times higher than their international reference price and as high as about 16 times that price in some countries [4]
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