Formulation development and evaluation of directly compressed polyherbal tablets for the management of infections caused by helminthes

Abstract

In current-scenario the traditional remedies are widely accepted globally. Lots of semisynthetic as well synthetic drugs are available all over the world. The poly-herbal remedies are harmless alternatives for the treatment of obese patients and it has less side effects. Parasitic infections like worm infections are common infection that affecting wide-range of people world-wide, while easily cured/treated by plant derived medicines/herbal remedies. The aim of the current study is to formulate a polyherbal tablets (antihelminthic tablets) including compositions like Ginger, Fenugreek seeds, Spinacia oleracea leave, Baliospermum montanum muell, Curcuminoids, Lycopene, vitex Negundo by direct compression method by using several excipients and subjected for the assessment of pre-compression as well post-compression parameters. Finally, for in-vivo assessment of the unit dosage form was done on rats. The formulation of polyherbal tablets has been developed with the aid of design expert software. The formulation F19 is provided in both pre compression and post-compression parameters. Good outcomes for all formulations designed. The findings of the stability research indicated that polyherbal tablets had been stable during all the experiments. The results reveal that the F19 formulation was superior based on the tablet evaluation. All excerpts exhibited inhibitor efficacy in the treatment of obesity against helminthics.