Formulation development and evaluation of novel polyherbal tablet with complete antidiabetic solution

Abstract

Four herbal drugs with the complete antidiabetic solution were selected based on documented properties. Poly-herbal combinations containing 50 % hydro-alcoholic extracts, having the most significant overall antidiabetic activity were selected and polyherbal uncoated tablet (PHUT) was developed. 500 mg PHUT were developed, by homogeneously mixing 250 mg/tablet, dried and finely powdered extracts of four herbs in the most effective ratio, i.e. H. sabdariffa (100): A. marmelos (50): F. religiosa (75): A. squamosa (25), with excipients (250 mg/tablet) by direct compression method. For formulation optimization, 3 different formulations were developed by using the same excipients in different ratios and were evaluated for good flow properties and good packing ability. After pre-compression studies, powdered blends were directly compressed and were evaluated using post-compression parameters. Developed PHUTs were dark reddish-brown and devoid of any rough surface. Post compression parameters showed that all parameters are within the limit for all PHUT formulations. Out of all, PHUT 3 showed a significant average disintegration time of 9.40 minutes; hence it was considered as an optimized formulation and was subjected to 3 months accelerated stability studies. Where no significant changes were observed, PHUT 3 was considered a standard formulation with a complete antidiabetic solution.