Abstract
The objective of our study was to form a novel method of delivering drugs that would improve the effectiveness of valganciclovir, an antiviral medication used to treat cytomegalovirus (CMV) infection in individuals with weakened immune systems. The drug’s induction dosage has limited penetration and requires very high doses. The nanosponges were synthesized using the emulsion solvent diffusion method, employing a 32 full factorial design to determine the combined impact of 2 independent variables: Quantity of ethyl cellulose and stirring speed. The dependent variables assessed were zeta potential, polydispersity index (PDI), and entrapment efficiency. Improved formulation exhibited an entrapment efficiency of 83.61%, a zeta potential. of -17.6 mV, and a PDI of 0.51. The improved formulation exhibited a continuous and controlled release of the medication. The produced nanosponges were characterized using fourier transform infrared (FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM).
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