Abstract
Objectives: The present study aims on preparing Levosulpiride loaded solid lipid nanoparticles (SLNs) to reduce the dose, frequency of dosing, reduce side effects and to increase the bioavailable fraction of drug (<30% orally in general). Methods: Levosulpiride was characterized by preformulation studies like physical appearance, melting point, assay, calibration curve, FTIR analysis and DSC analysis. The calibration curve of the drug was prepared in pH 6.8 phosphate buffer. Two lipids (Stearic acid and Palmitic acid) were used as lipid phase to prepare SLNs. Factorial design (23) was applied to formulate 16 formulations (8 for each lipid i.e. SF1-SF8 and PF1-PF8). Levosulpiride SLNs were prepared by solvent evaporation method followed by homogenization. Results: The optimized formulations were characterized by particle size analysis, zeta potential analysis, in vitro drug release and drug release kinetics. Drug-excipient interaction in optimized formulation was characterized by FTIR, DSC and TEM analysis. Conclusion: On the basis of evaluation parameters, the formulation SF1 (containing Stearic acid) and PF1 (containing Palimitic acid) found to be better formulations amongst their groups with a controlled drug release after a period of 24 hrs.
Highlights
In the recent years, with the advent of Nanomedicine, engineered tunable devices with the size in the order of billions of meters have been proposed as an intriguing tool potentially able to solve the unmet problem of enhancing drug transport across the BBB [1]
Optimized formulations were characterized for particle size analysis, zeta potential, drug entrapment efficiency and in vitro drug release study
The particle size of SF1, SF2, SF6, PF1, PF2 and PF6 was measured to be 124.4 nm, 179.3 nm, 143.8 nm, 137.1, 189.7 and 154.1 nm respectively using Zetasizer, which was in desired range
Summary
With the advent of Nanomedicine, engineered tunable devices with the size in the order of billions of meters have been proposed as an intriguing tool potentially able to solve the unmet problem of enhancing drug transport across the BBB [1]. Nanotechnology refers to structures with a size range of 1–100 nm in at least one dimension [2]. Nanotechnology is the application of science and technology to control matter at the molecular level. Nanotechnology refers to the ability for designing, characterization, production and application of structures, devices and systems by controlling shape and size at the nanometer scale. One area where nanotechnology has the potential to make a significant impact is drug [4]. This impact has already been felt with the translation of several nanoscale drug delivery systems into the clinic, the full potential of these systems is only starting to be explored.
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