Formulation and evaluation of herbal tablet containing Terminalia chebula extract

Abstract

According to WHO, the prevalence of diabetes is likely to increase by 35%. Currently there are over 150 million diabetics worldwide and this is likely to increase to 300 million or more by the year 2025. International Diabetes Federation (IFD) estimates the total number of diabetic subjects to be around 40.9 million in India and this if further set to rise to 66.9 million by the 2025. In view of the above discussion this study was undertaken to investigate antidiabetic activity of herbal tablet of Terminalia chebula in alloxan induced diabetic rats. Solid pharmaceutical dosage formulations using a novel dry plant extract (Terminalia chebula fruits) using various excipients i.e.carbopol, lactose, gelatin, magnesium stearate and dicalcium phosphate by the wet granulation was reported to the statically significant. The present communication deals with the evaluation of formulated tablets (weight variation, friability and hardness and disintegration time). Diabetes was induced in Wistar albino rats (170-200g) by a single dose (I.P.) of alloxan monohydrate (150mg/kg) dissolved in normal saline, treatment were given orally for 21days and blood glucose level was estimated on Two different batches of herbal tablets of Terminalia chebula extract (carbopol & gelatin) were studied for blood glucose level in two different groups of animals. Oral administration of Terminalia chebula tablet having carbopol to diabetic rats at a dose of 200mg/kg body weight to wistar rats in a significant reduction in biochemical parameters in alloxan diabetic rats, and the best formulation according to disintegration time. Thus our investigation clearly shows that the Terminalia chebula tablet has antidiabetic effects.