Abstract
Calcium channel blocker diltiazem hydrochloride is used to treat hypertension and angina. The study aimed to develop and evaluate bioadhesive buccal tablets that would bypass hepatic metabolism and boost bioavailability. With the use of bioadhesive polymers like kondagogu gum and guar gum in various concentrations, the direct compression method was used to manufacture buccal tablets. Fourier-transform spectroscopy (FT-IR) spectroscopy analysis of the physicochemical compatibility of the active ingredient and excipients demonstrates that the excipients are compatible with the active component. Permeation across porcine buccal mucosa, moisture absorbance, in-vitro drug release, surface pH, and swelling index were all tested on the developed tablets. The best formulation, which contained a combination of kondagogu gum and guar gum (F8), was the most effective, showing a flux of 208.46 μg hr-1 cm-2.
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