Abstract
A novel concept of liquisolid technique is where a liquid is converted to dry flow able and compressible powder by mixing with appropriate carrier and coating material. Improved in-vitro dissolution property of partially soluble Acetazolamide was explored by possible liquisolid technique. Liquisolid formulations were prepared by suspending Acetazolamide in PEG 400Tween 80propylene glycol with Avicel PH 102 and HPMC K4M Aerosil 200 and Sodium starch glycolateas carrier coating material and disintegrating agent respectively. Drug excipients interactions were studied by FT-IR Spetroscopy. Solubility of the drug in the solvent was determined as showed PEG400 86.4mgmlPG 66.6mgml and Tween 8034.2mgml. Disintegration between 80 ndash 95 Sec. Dissolution profile percentage of F1 98.21 within 20 min showed is better than the formulations prepared by direct compression which increased surface area and wetting properties through liquisolid method. Itrsquos a determinative move to improve dissolution by liquisolid method of partially water soluble drug
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