Abstract
The dried root of Asparagus racemosus is widely used as mild antihypertensive and tranquilizer. The objective of the present research was to study the original flowability, compressibility and compactibility of Asparagus racemosus root powder and develop its tablet formulations by wet granulation and direct compression technology. The consolidation behavior of drug and tablet formulations were studied by using Heckel and Leuenberger equation. Asparagus racemosus root powder showed very poor flowability and compactibility. Kawakita analysis revealed improved flowability for formulations prepared by direct compression and wet granulation technique. The Heckel plot showed that Asparagus racemosus powder is soft in nature and poor in die filling. Granules showed higher degree of plasticity and fragmentation than powder and direct compression formulations. The compression susceptibility parameter for compact formed by direct compression and wet granulation technique indicated that the maximum crushing strength is reached faster at lower pressures of compression as opposed to Asparagus racemosus powder. From this study, it is concluded that desired flowability, compressibility and compactibility of Asparagus racemosus root powder can be obtained by direct compression and wet granulation technique
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