Formation of Nα-benzyloxycarbonyl- l-aminoadipic acid from Nα-benzyloxycarbonyl- l-lysine with mycelia from Aspergillus niger

Abstract

A method for formation of N α-benzyloxycarbonyl- l-aminoadipic acid ( N α- Z- l-AAA) was investigated. N α- Z- l-AAA was formed from N α- Z- l-lysine via N α- Z- l-aminoadipate-δ-semialdehyde ( N α- Z- l-AASA) by the reaction with mycelia from Aspergillus niger according to Scheme 1. In this reaction, oxidation of N α- Z- l-lysine to N α- Z- l-AASA was catalyzed by amine oxidase. The reaction at pH 7.0 and 30 °C was optimum for N α- Z- l-AAA formation, and approximately 50% of the decomposed N α- Z- l-lysine was converted into N α- Z- l-AAA.