Abstract
The results of correlation analysis between biochemical parameters of type 2 diabetes mellitus and markers of liver enantiosis among the population of Dnipro with a total number of 400 people, 200 men and women are presented. Patients were divided into experimental age groups: 1 – 21-45 years; 2 – 46-55 years; 3 – 56-64 years; 4 – 65 years and older.Determination of biochemical markers of carbohydrate, lipid metabolism and liver profile was performed by kinetic, colourimetric, chemiluminescent methods and the method of high-performance liquid chromatography. Correlations have been established that characterize the peculiarities of the formation of types of insulin resistance in type 2 diabetes in men and women, which affects the metabolic processes of the main energy sources. A strong direct correlation of high significance between the HOMA index and biochemical parameters of hepatic enantiosis indicates the formation of hepatic insulin resistance in men aged 21 years, in women over 65 years. It was found that men aged 21-45 years develop hepatic insulin resistance with changes in lipid metabolism in adipose tissue, women of the same age group – insulin resistance of adiposetissue with changes in lipid metabolism in the liver. Correlation analysis has shown that the most vulnerable area of the liver in type 2 diabetes is the hepatic triad, which is accompanied by a 3-4-fold increase in γ-glutamyltransferase activity and strong links of high significance with insulin concentration, HOMA index. The atherogenic factor has a significant diagnostic value only for women aged 21-45 years and over 65 years, which is confirmed by correlations.
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