Foresightedness research of three dimensional conformal radiotherapy and complex therapy for primary hepatic cancer

Abstract

Objective To compare the therapeutic effects of transcatheter hepatic chemoembolization (TACE) alone、 three dimensional conformal radiotherapy (3 DCRT) alone,and TACE + 3 DCRT.Methods 67 patients with primary hepatic cacer were randomized divided into three groups:A-25patients were treated with 1-5 times of TACE alone;B-20 patients,radiotherapy with 3DCRT 45-60 Gy average 50 Gy;Group c-22 patients,TACE plus radiotherapy,at the first time were received 1-4 times of TACE by radiotherapy,then with 3DCRT after a rest of 4-8 week.for TACE,1000-1250 mg 5-fluorouracil and 20-30 mg hydroxyeamptothecine were perfused into the hepatic arteries,then 60-80 mg cisplatin and 14-20 mg mitomycin(or 50-60 mg epirubicin)and iodized oil 10-30 ml were given to embolized the hepatic arteries which was then followed by 1-2 mm gelform spieces.For 3DCRT,radiation was given by 6MV X-ray.Results The overall survivals at 1-,2-and 3-years were 61.3% ,34.0% and 19.0%for A-group TACE alone,53.1% ,31.3% and 18.8% for B-group 3DCRT;74.8%,57.0% and 40.4% for C-group TACE + 3DCRT.The differences in the survivals are statistically significant(P ＜0.05).the main complication was fever.Conclusion Treatment result of TACE + 3DCRT is better than TACE alone or3DCRTalone. Key words: Liver neoplansms/therapy; Liver neoplasms/radiotherapy; Embolization; Therapeutic