Abstract
Objective To compare the therapeutic effects of transcatheter hepatic chemoembolization (TACE) alone、 three dimensional conformal radiotherapy (3 DCRT) alone,and TACE + 3 DCRT.Methods 67 patients with primary hepatic cacer were randomized divided into three groups:A-25patients were treated with 1-5 times of TACE alone;B-20 patients,radiotherapy with 3DCRT 45-60 Gy average 50 Gy;Group c-22 patients,TACE plus radiotherapy,at the first time were received 1-4 times of TACE by radiotherapy,then with 3DCRT after a rest of 4-8 week.for TACE,1000-1250 mg 5-fluorouracil and 20-30 mg hydroxyeamptothecine were perfused into the hepatic arteries,then 60-80 mg cisplatin and 14-20 mg mitomycin(or 50-60 mg epirubicin)and iodized oil 10-30 ml were given to embolized the hepatic arteries which was then followed by 1-2 mm gelform spieces.For 3DCRT,radiation was given by 6MV X-ray.Results The overall survivals at 1-,2-and 3-years were 61.3% ,34.0% and 19.0%for A-group TACE alone,53.1% ,31.3% and 18.8% for B-group 3DCRT;74.8%,57.0% and 40.4% for C-group TACE + 3DCRT.The differences in the survivals are statistically significant(P <0.05).the main complication was fever.Conclusion Treatment result of TACE + 3DCRT is better than TACE alone or3DCRTalone. Key words: Liver neoplansms/therapy; Liver neoplasms/radiotherapy; Embolization; Therapeutic
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