Abstract
Ethyl alcohol and carbon monoxide are among the most common toxic substances that can be fatal. However, morphological changes in this pathological condition are insufficiently studied. A new step was the development and application of laser polarimetric methods for microscopic study of optically inhomogeneous biological structures using statistical analysis of digital polarization maps. This work is aimed at studying and substantiating the information possibilities of the objective method of Stokes-polarimetric microscopy of histological sections of biological tissues (BT) in the differential diagnosis of alcohol and carbon monoxide poisoning.Aim of the work. To develop a set of forensic objective criteria to increase the possibility of differential diagnosis of ethanol and carbon monoxide poisoning according to Stokes-polarimetric mapping of polycrystalline structure of blood films and human myocardium.Materials and methods. The object of the study were histological sections of the myocardium and polycrystalline blood films obtained from 68 corpses of both sexes, aged 18 to 75 years. BT samples from deaths due to ischemic heart disease (ІHD) were used for control. The study was performed by Stokes polarimetric mapping of microscopic images of biological layers.Results. Comparative analysis of polarization maps of the crystallization parameter (CP) and histograms of the distributions of the 4th parameter of the Stokes vector showed greater sensitivity of the Stokes-polarimetric mapping method of digital microscopic images of polycrystalline blood films to degenerative-dystrophic changes for alcohol and carbon monoxide poisoning. histological sections of the myocardium. Moreover, the most informative were the statistical moments of the 3rd - 4th orders, which characterize the coordinate distributions of the PC size of microscopic images of samples of polycrystalline blood films.Conclusion. The possibility of statistically significant (p1; p2<0.05) differentiation of deaths due to alcohol and carbon monoxide poisoning by calculating statistical moments of higher orders (asymmetry As and excess Ek), which characterize the PC size distributions of microscopic images of polycrystalline blood films, has been established.
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