Acute carbon monoxide poisoning and delayed neurological sequelae: a potential neuroprotection bundle therapy

Abstract

Currently, there is no known optimal therapy for carbon monoxide (CO) poisoning and CO-associated delayed neurological sequelae. Hyperbaric oxygen therapy (HBOT) is a well-known treatment method, but its use for CO poisoning patients is controversial to use due to lack of evidences regarding its efficacy. Thus, it is unlikely that HBOT alone will be accepted as the standard treatment method. In this article, current and potential treatment methods of CO poisoning are presented as well as the tentative multi-factorial pathophysiology. A series of treatments are suggested for use as a bundle therapy, with targeted temperature management as the base treatment method. Such a therapy holds a great potential, especially for the cases where HBOT is not readily available. We suggest further investigations for elucidating the effects of these suggested treatments and their roles in terms of the complex pathophysiology of CO poisoning. Future acceptance of this therapy based on the improved scientific and clinical knowledge may result in injury prevention and minimization of the signs and the symptoms in CO poisoning.