Abstract
In this paper we show that the control of adhesion in highly flexible (a property that couldbe crucial for smart drug delivery but which is still ignored in the literature) nanovectorscan help in smartly targeting and delivering the drug. The existence of and the conditionsfor activating and controlling a super-adhesive state are addressed. Even if such a statehas never been observed in nanovectors, our calculations, as well as observationsin spiders and geckos, suggest its existence and feasible control. Control of thecompetition between the drag and the adhesive force is exploited to improve thetargeting ability and a hierarchical model is applied to describe a real vasculature.The high flexibility of the nanovector is used to smartly deliver the drug onlyduring adhesion by nanopumping or, as a limiting case, by the new concept of‘adhesion induced nanovector implosion’; a liquid drop analogy is utilized for thecalculations. Fast (pumping) and slow (diffusion) drug deliveries can thus be separatelycontrolled by controlling the size and shape of the nanovector. Multiple stagenanovectors are also briefly discussed, mimicking aerospace vector strategies.
Published Version
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