Abstract
Covalent organic frameworks (COFs) are porous materials constructed using organic building units which are connected through strong covalent bonds. COFs are studied for a range of applications from energy storage to medical applications. Recently, COFs are used as targeted drug transport and delivery vehicles to achieve desired therapeutic effects. COFs are extensively used in drug delivery as it is easy to customize them for targeted drug delivery applications and improved bioavailability and to provide a controlled drug release. They possess some distinctive features such as a large surface area, high porosity, crystallinity, and high flexibility. Compared to traditional metal-organic frameworks (MOFs), COFs do not possess toxic, heavy, and hydrolyzable metals or metal oxides. Thereby, they lower the degree of unwanted toxicity and can be used as a safe drug carrier. Such porous biomaterials-based COFs broaden a spectrum of opportunities in drug delivery formulation to address and treat challenging diseases. Although this field of medicinal chemistry is currently at its infancy stage, COFs have paved a new means to meet upcoming challenges in healthcare and disease theragnostic. This chapter aims to explain the use of COFs in drug delivery by highlighting their types, synthetic protocols, and their drug-loading and release performances.
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