Abstract
Fisher's syndrome and Bickerstaff's brainstem encephalitis share clinical and serological features. In Fisher's syndrome, patients have a clinical triad of ophthalmoplegia, ataxia, and areflexia, whereas in Bickerstaff's brainstem encephalitis, patients present with ophthalmoplegia, ataxia, and apparent central nervous system (CNS) signs such as altered consciousness and hyperreflexia. Both conditions can develop after infections by Campylobacter jejuni or Haemophilus influenzae and are associated with IgG autoantibodies against GQ1b. The similar features of the two conditions suggest that they are part of a spectrum affecting the peripheral nervous system and CNS.
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