Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine

Maciej Boguń,Izabella Krucińska,Anna Ścisłowska-Czarnecka,Agnieszka Kommisarczyk,Teresa Mikołajczyk,Elżbieta Menaszek,Marta Błażewicz,Ewa Stodolak-Zych

doi:10.3390/molecules18033118

Abstract

This work concerns the production of fibrous composite materials based on biodegradable polymers such as alginate, dibutyryl chitin (DBC) and poly-ε-caprolactone (PCL). For the production of fibres from these polymers, various spinning methods were used in order to obtain composite materials of different composition and structure. In the case of alginate fibres containing the nanoadditive tricalcium phosphate (TCP), the traditional method of forming fibres wet from solution was used. However in the case of the other two polymers the electrospinning method was used. Two model systems were tested for biocompatibility. The physicochemical and basic biological tests carried out show that the submicron fibres produced using PCL and DBC have good biocompatibility. The proposed hybrid systems composed of micrometric fibres (zinc and calcium alginates containing TCP) and submicron fibres (DBC and PCL) meet the requirements of regenerative medicine. The biomimetic fibre system, the presence of TCP nanoadditive, and the use of polymers with different resorption times provide a framework with specific properties on which bone cells are able to settle and proliferate.

Highlights

The needs of the market for modern implant materials are stimulating the rapid development of regenerative medicine, and especially of tissue engineering, whose task is to assist the reconstruction of damaged tissues [1]
The study used zinc and calcium alginate fibres with 3% tricalcium phosphate (TCP) nanoadditive introduced into the fibre material
The tests carried out on submicron fibres obtained by electrospinning showed that they are a biocompatible material characterized by good adhesion of cells to their surface

Summary

Introduction

The needs of the market for modern implant materials are stimulating the rapid development of regenerative medicine, and especially of tissue engineering, whose task is to assist the reconstruction of damaged tissues [1]. The development of this field of medicine based on a new class of biomaterial engineering solutions is making a significant contribution in terms of both shortening patient hospitalization times and bringing notable economic benefits. A important role among materials in this category is played by composites made from biodegradable and bioresorbable polymers.

Objectives

Methods

Results

Conclusion