Abstract
The aim of this scientific work was to determine the influence of the experimental fetoplacental insufficiency on the both sex offspring oxidative status during puberty and to estimate the efficiency of base and complextherapy during pregnancy.Materials. The healthy, Vistar mature rat’s females of young (3–4 months) and mature (8–10 months)reproductive age have been used for both sex offspring obtaining. 8 groups for 7 pregnant females in eachhave been formed: Groups I and II — intact animals of young and mature reproductive age; Group III andIV — females with experimental Fetoplacental insufficiency (FPI) of young and mature reproductive age accordingly; Groups V and VI — young and mature animals with experimental FPI treated by pharmaceuticalcomposition which contains nontoxic active pharmaceutical ingredients of FPI basic therapeutic group — aminoacid (L-arginine), dicarbonic acid (succinic acid), vitamins (folic acid) and vasoactive drug (dipyridamole).Experimental animals have received treatment from 11 to 19 day of pregnancy. Groups VII and VIII — youngand mature animals with experimental FPI treated by drug of comparison — dipyridamole. The modeling ofFPI has been carried out by daily subcutaneous introduction of 50 % tetrachlormethane oil solution in dose of2 ml/kg of body weight from 12 to 18 day of pregnancy. Animals — offspring have been killed on the 50th day oflife (puberty period) by quick decapitation without general anesthesia to avoid negative effects on sex hormoneslevel and antioxidant enzymes systems.Results. The effect of experimental fetoplacental insufficiency in rats of young and mature reproductiveage on the oxidative status formation in offspring of both sexes during puberty was determined and the effectsof basic and complex therapy during pregnancy were evaluated. It was revealed that fetoplacental insufficiencyin the second half of pregnancy leads to the formation in offspring of both sexes, but more pronounced in maleoffspring, during the puberty, an altered pattern of the antioxidant system enzymatic activity, which is realizedin increased levels of both primary and final products of lipoperoxidation and may be the basis for further development of chronic diseases. More pronounced disorders were observed in the offspring of mothers of maturereproductive age, which may be due to the additional influence of involutive processes in the placenta. The useof a vasodilator drug alone and, more effectively in combination, significantly restored the studied parameters
Highlights
The main scientific purposes of physiologists and pathophysiologists investigations during many years are particularities of the individual organism developing and mechanisms of pathologies forming in mammalians inclu ding men
The epigenetic programming of gametes, embryonic cells and tissues and stem cells developing during critical «window» of ontogenesis was linked to phenomenon mentioned above
According to the current ideas, the increasing of lipid peroxidation (LP) is important pathogenetic part of any stress influence, the cause of membranes structure and functioning disturbances including mitochondrial membranes
Summary
The main scientific purposes of physiologists and pathophysiologists investigations during many years are particularities of the individual organism developing and mechanisms of pathologies forming in mammalians inclu ding men. Fetoplacental insufficiency (FPI) is widespread clinic syndrome caused by uncompensated morphological and functional placental changes, accompanies with the disturbances of uterus-placental blood circulation and, respectively, with trophic fails, distress and fetus hypoxia, that are manifested in fetus growing and developing modifications [3-5]. The epigenetic programming of gametes, embryonic cells and tissues and stem cells developing during critical «window» (sensitive period) of ontogenesis was linked to phenomenon mentioned above During this sensitive period, adverse impact on mother’s organism causes disturbances of pregnancy, regulates fetal growing and leads to disease developing in later life [7, 8]. There are some controversial experimental data about fetal oxidative stress influence on forming sexdepending predisposition for developing some chronic pathologies with age, such as obesity, metabolic syndrome, endothelian dysfunction and cardio-vascular disease [11, 12]. The aim of this scientific work was to determine the influence of the experimental fetoplacental insufficiency on the both sex offspring oxidative status during puberty and to estimate the efficiency of base and complex therapy during pregnancy
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