Abstract
The penetration of the toxic substances into mother's organism leads to the cumulative xenobiotic burden of different degree with the following induction of removal reactions and developing of obstetric complications, and may cause the metabolic form of fetoplacental insufficiency. The pathogenesis of the fetoplacental insufficiency is determined by morphological changes and disturbances of placenta functioning. The purposes of this work were to study influence of further consequences of experimental fetoplacental insufficiency in mothers of young and mature reproductive age on the females-offspring fertility and to investigate the protective properties of original pharmaceutical composition.Materials and methods. The healthy, Vistar mature rat's females of young (3 months) and mature (10 months) reproductive age have been used in the experiment. 8 groups for 7 pregnant females in each have been formed: groups 1 and 2 — intact animals of young and mature reproductive age; groups 3 and 4 — females with experimental fetoplacental insufficiency of young and mature reproductive age accordingly; groups 5 and 6 — young and mature animals with experimental fetoplacental insufficiency treated by pharmaceutical composition from 11 to 19 day of pregnancy. Groups 7 and 8 — young and mature animals with experimental fetoplacental insufficiency treated by drug of comparison – Dipyridamole. The modeling of fetoplacental insufficiency has been fulfilled by daily subcutaneous introduction of 50% tetrachloromethane oil solution in dose of 2 ml/kg of body mass from 12 to 18 day of pregnancy. The fertility of females has been determined according to the results of mating with intact healthy males. The blood serum samples have been obtained for Estradiol and Testosterone levels determination.Results. Fetoplacental insufficiency influences the fertility of females-offspring born to mothers of young and mature reproductive age. Аll the groups of females-offspring born to mothers with fetoplacental insufficiency have significantly lowered pregnancy index and integral fecundity. Only in offspring born to mothers of young reproductive age with fetoplacental insufficiency the decreased number of pregnancy corpus luteum, implantation sites and fetuses has been observed. The introduction of pharmaceutical composition to pregnant females has lead to female birth with normalized levels of sex hormones, nevertheless, animals has demonstrated decreased fecundity.
Highlights
IntroductionЕкспериментальні дослідження ces in developing and functioning of different systems and organs in the postnatal period of life
As for reproductive system of offspring born to mothers with fetoplacental insufficiency (FPI), there were single investigations which reported about sexual developing and hormonal status of male child ren, but the given data were controversial and non-comparable due to different procedures of hormone determination and FPI interpetation [11, 12]
The presence of the sperm cells in morning vaginal swabs has been considered to be the first day of pregnancy. 8 groups for 7 pregnant females in each have been formed: groups 1 and 2 — intact animals of young and mature reproductive age; groups 3 and 4 — females with experimental FPI of young and mature reproductive age ; groups 5 and 6 — young and mature animals with experimental FPI treated by pharmaceutical composition, which contains nonfetotoxic active pharmaceutical ingredients of FPI basic therapeutic group — amino acid (L-arginine), dicarbonic acid, vitamins and vasoactive drug (Dipyridamole)
Summary
Експериментальні дослідження ces in developing and functioning of different systems and organs in the postnatal period of life. As for female offspring, it has been determined that ovaries structure of offspring born to mothers with complicated pregnancy, corresponds to hypoplastic type and testifies low functional activity of fetal gonads, which may lead to further disturbances of germinative function of woman organism [13]. It is proved that giving birth after 35 has often caused the pregnancy complications. According to the literature data, the substantial part of such pregnancies is complicated by FPI [15] These women need the treatment or prophylaxis by many drugs. The purposes of this work were to study influence of further consequences of experimental FPI in mothers of young and mature reproductive age on the females-offspring fertility and to investigate the protective pro perties of original pharmaceutical composition (PhC)
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