Features of the influence of Оmega-3 fatty acids on the course of inflammatory and immune reactions

Abstract

Under the influence of polyunsaturated fatty acids in the human body are complex biochemical processes. Their influence on the functioning of cells is to ensure the stability of the cell membrane, maintaining the energy balance in the cell, the influence on the synthesis of specific substances - eicosanoids and more. Omega-3 PUFAs reduce the activity of the inflammatory process, as they produce specific mediators to reduce inflammation, and also have a depressant effect on the synthesis of proinflammatory substances (cyclooxygenase 2, nitric oxide synthase, tumor necrosis factor (TNF), interleukins 1, 6 and 12 in endothelial cells, etc.). Due to these properties of Omega-3 fatty acids promote an active immune response to external stimuli, as well as accelerate recovery from exacerbations of chronic diseases. In particular, in the exacerbation of Chronic obstructive pulmonary disease (COPD), the appointment of Оmega-3, due to its anti-inflammatory properties, helps to quickly reduce the effects of endobronchitis. Adding Оmega-3 to the diet has a positive effect on the immune system and prevents the development of exacerbations of chronic diseases.