Abstract
Prosopis africana, Family Leguminoceae, is used in ethnomedicine to treat different ailments including, diarrhoea, bacillary dysentery, malaria, male sterility and as a cardiotonic. This research aims at evaluating the antibacterial and antituberculosis activities of fatty alcohol. Heneicosanol (1), hexacosanol (2), nonacosanol (3), β-sitosterol (4), quercetin (5), β-sitosterol 3-O-β-D-glucopyranoside (6) and quercitrin (7) were isolated from the leaves of Prosopis africana. Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. Heneicosanol (1), hexacosanol (2), nonacosanol (3) were isolated for the first time to this plant and was subject of antibacterial and antituberculosis activities. The results of this study suggest that the compounds 1, 2, 3 had an MBC a respective value of 1.56 µg/mL, 1.62 µg/mL, 0.12 µg/mL against M. smegmatis, M. tuberculosis. The study of fatty alcohols provides evidence of activity against clinical isolate of mycobacteria, significant anti-inflammatory and analgesic properties, and provides a basis for its possible use as an affordable and effective Antituberculosis agent from natural product.
Highlights
Woody plants have been known to produce many biologically active metabolites
Fractionation of the nhexane and EtOAc-soluble fractions by silica gel open column (CC) and flash column (FC) chromatography resulted in the isolation of seven compounds 1-7 (Figure 1)
The results provide a rationale for the use of Prosopis africana in traditional medicine to treat various diseases
Summary
Woody plants have been known to produce many biologically active metabolites. In addition to the studies on chemical constituents of herbal medicinal plants, our phytochemical program targets woody plants as potential sources of useful natural compounds. The study on Prosopis africana should be of interest since the constituents of Prosopis species have been demonstrated to possess antioxidant [3, 4], anti-inflammatory [5,6,7,8], anticancer [9, 10] and hepatoprotective effects [3, 11]. In this paper the isolation and structural elucidation of seven compounds, heneicosanol (1), hexacosanol (2), nonacosanol (3), βsitosterol (4), quercetin (5), β-sitosterol 3-O-β-Dglucopyranoside (6), and quercitrin (7) (Figure 1) from the MeOH extract of the leaves of Prosopis aficana. Heneicosanol (1), hexacosanol (2), nonacosanol (3) were isolated from this plant for the first time. The goal of this study is evaluating the antibacterial and antituberculosis activities of the fatty alcohol isolated for the first time from the leaves of Prosopis africana
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