Abstract
A study of fatty acid oxidation in chick embryos and hatched chicks has shown that the oxidation of long chain and short chain fatty acids conforms with the mechanism shown in adult mammalian tissue. Carnitine was required for maximal oxidation of long-chain fatty acids even though carnitine could be shown to be present in a relatively constant concentration throughout incubation. The rate of oxidation of fatty acids increased with time of incubation in heart tissue except for a transient decrease before hatching, whereas in liver there was a progessive decrease until hatching. The specific activities of enoyl-CoA hydratase (EC 4.2.1.17) β-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) and acetyl-CoA acetyltransferase (EC 2.3.1.9) in the embryo heart mitochondria increased with time of incubation. The increase in rate of fatty acid oxidation by the embryo heart mitochondria was not accompanied by a similar increase in the rate of oxidation of α-ketoglutarate or succinate. These findings suggested a change in heart mitochondrial composition or function with development.
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