Abstract
Craniosynostosis(CS) is a disease in which one or more of the skull sutures to close early, which limits the growth of the bone site, resulting in anomalous skulls. This study aims to expose the population, through citations and discussions, the causal factors of CS, promoting an autonomy of the individuals, through greater knowledge of the subject, intending, thereby, open paths for the development of actions that aim decrease the incidence this comorbity. Was conducted a revision of articles published only in English and were found related with CS genetic factors, teratogen, smoking during pregnancy, advanced parental age, educational levels of parents, use of antidepressants in pregnancy, stimulation by thyroid hormones, with methotrexate therapy, metabolic conditions and intake of certain nutrients, showing the mechanisms for the formation this disease. The knowledge about the causal factorsbecome important for the define of strategies that aim decrease the incidence of CS.
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