Fast Fourier Transformed Twin Table Ladder Modulation on Recognising Non Invasive Blood Glucose Level Measurement Optical Device Spectral Responses

Abstract

A comparative trial conducted between February 2017 and April 2017, at Electronic Material Physics Laboratory, Department of Physics, Bogor Agricultural University, West Java, Indonesia. Blood spectral data from participant older than 17 years were assigned to single measurement group. Blood spectral data previously taken from All participant modulated using Twin Table and Ladder (TTL) methods, and further transformed using Fast Fourier Transform (FFT) Methods, and inferred using Fast Artificial Neural Network. The data contained blood glucose level measurement using both prototype of non invasive blood glucose level measurement optical device (prototype) and veni puncture spectrophotometry (veni). The objective was to measure effect of FFT on accuracy of TTL based optical spectral parser engine for prototype compared to veni for fasting normo glucose participants (participants). Main outcome measure: accuracy as rooted means squared error (RMSE) of either TTL and FFT - TTL inference method, smaller is better. Clarke error grid analysis (ega) and Parker ega, and sensitivity and specificity are calculated from the outcomes, larger is better. No randomization of records. The data was inferred using TTL method, and further transformed using FFT method. Analyser are not blinded for either measurement methods. 120 blood spectrum data from volunteerd included in measurement group. The trial is completed for current prototype version, and shall be reopened for future versions. 110 datums were included in the analysis of the primary outcome. RMSE of FFT-TTL 5.16 mg / dl is smaller than TTL 5.27 mg / dl. No difference between Parkes ega of FFT-TTL and pure TTL. There is insignificant increase in Clarke ega, 99.5 % group A in FFT-TTL compared to 99.3 % group A in TTL. There significance increase of specificity (0.76) but also decrease of sensitivity (0.65) of FFT-TTL compared to TTL. (0.67 and 9.72). Diagnostic accuracy (0.71) and odd ratio (5.83), and Youden index (0.41) remain not changed. No apparent possible case for adverse effect for either methods. No Significant Performance Difference on Fast Fourier Transformed Twin Table Ladder Modulation on Recognising Non Invasive Blood Glucose Level Measurement Optical Device Spectral Responses.