False positive detection of serum cryptococcal antigens due to insufficient sample dilution: A case series.

Abstract

In the three cases we reported, we found that insufficient dilution of the samples may lead to false-positive results in the detection of cryptococcal capsule antigen, which has never been reported before. Therefore, once the test results are inconsistent with the clinical symptoms, it is necessary to reexamine the samples carefully. Especially for LFA and LA, the samples can be fully diluted or segmented diluted to avoid false-positive results. It is certain that in the diagnosis, fluid and tissue culture should also be improved, combined with imaging, ink staining, and other methods to improve the accuracy of the diagnosis further.