Abstract
The Reformatsky reaction between α-haloester and a carbonyl compound constitutes one of the most useful methods for carbon-carbon bond formation in organic synthesis. It offers the advantages of regioselective enolate formation under nearly neutral conditions. However, the classic method employing zinc dust as a reductant can be plagued by extended reaction times and byproduct formation. To address these concerns, besides the classical zinc enolate, various metal enolates have been examined so far, of which indium enolate was first introduced to organic synthesis in 1975. The scope of the Reformatsky reaction has progressed through the years and is the subject of several reviews. It has recently been reported that organoindium reagents, prepared from α-haloester and metallic indium,
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