Facile Synthesis of Copper‐5‐Aminoisophthalic Acid Metal Organic Framework as a Potential Drug Carrier for Ibuprofen

Abstract

AbstractDue to their large surface area and porous nature, metal organic frameworks hold a promising application in drug delivery. Among several combinations of metals with organic linkers, copper as a metal possesses synergistic behavior in drug delivery due to its antibacterial, antioxidant properties, and other biological functional necessities. This study uses the copper‐5‐aminoisophthalic acid metal organic framework (AIPA‐Cu (II) MOF) for drug delivery. From the experimental studies, AIPA‐Cu (II) MOF exhibited a potentially good loading capacity of Ibuprofen drug and excellent controlled release in in‐vitro drug release studies. The loading efficiency of Ibuprofen in AIPA‐Cu (II) MOF has been confirmed using BET adsorption, X‐Ray Diffraction, XPS spectroscopy, UV‐Visible Spectroscopy, and IR spectroscopy by comparing it against unloaded AIPA‐Cu (II) MOF. The uncoordinated free amino group in the 5‐aminoisophthalic acid ligand is expected to form an interaction between Ibuprofen and AIPA‐Cu (II) MOF through van der Waals force to induce better loading. Thus, the current study opens up a new avenue for the potential usage of AIPA‐Cu (II) MOF as an effective and compatible drug carrier for hydrophobic drugs like Ibuprofen.