Facile synthesis and optimization of CuONPs using Illicium verum & Polianthes tuberosa and their anticancer activity

Abstract

• The Copper oxide nanoparticles were successfully synthesized using extract of Star anise and Polianthes Tuberosa. • The plant material used was successfully acted as reducing agent, stabilizing and capping agents. • Synthesized Copper oxide nanoparticles were characterized by FT-IR, Ultraviolet–visible SEM & XRD techniques. • The size of the Copper oxide nanocrystals was 25.40 nm and 32.7 nm structure was monoclinic end-centered. • SEM analysis results sphere like shape and morphology for Copper oxide nanoparticles. • Showed significant anticancer activity against MM2 cancer cell line. Cancer has considered the second most deadly disease and causes more deaths in human beings without any age factors. Nowadays research is going on finding a potential drug to cure cancer. Especially nanoparticles are used for this process. In our research, we prepared CuONPs using an extract of Illicium verum and Polianthes tuberosa. Synthesized CuONPs have been characterized by using FT-IR, Ultraviolet–visible spectroscopic techniques, SEM, TEM& XRD techniques. The structure and size of the Copper oxide nanocrystals have been obtained from XRD analysis. The sizesof the Copper oxide nanocrystals have been found25.40 nm and 32.7 nm. XRD analysis results end-centered monoclinic structure of copper oxide nanocrystals. The sizes of CuONPs results from SEM have been 37.78 nm and 17.8 nm. The anticancer activity of CuONPs was tested against MM2 cell lines and showed significant activity. The results revealed that about 50 % of the cell viability (IC 50 ) was found to be at a 25 μg/mL concentration of CuONPs. Similarly, for CuONPs using Polianthes tuberosa , 50 % of the cell viability (IC 50 ) was found to be at a 20 μg/mL concentration of CuONPs. In the future, it could be used for further anticancer studies and drug discovery processes.