Abstract
Glassy carbon electrode (GCE) modified with poly(o-anisidine) and carbon nanotubes (POA/CNTs) nanocomposite was used for the sensitive and selective detection of a neurotransmitter dopamine (DA). The synthesized materials were characterized with different methods such as fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, x-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM), cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry. The modified electrode exhibited an influential and persistent electron mediating behaviour as a result of synergistic effects of the composite for the detection of DA. The prepared sensor could detect DA in the wide linear range from 10.0–260.0µM with a detection limit of 0.12µM (S/N = 3). The sensor exhibited excellent sensitivity, stability and reproducibility in the detecting process of DA. The fabricated sensor could favourably avoid the interference of glucose, ascorbic acid, uric acid, NADH and ethanol towards the detection of DA. The sensor was successfully applied to detect DA in real pharmaceutical samples with standard addition method.
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