Fabrication of biodegradable nano medical patches incorporating a sustained-release pharmacological agent using electro-spinning technique

Abstract

Nano-polymer (self-disappearing) medical patches loaded with a long-acting drug (each substance separately) were created by electro-spinning synthetic polymers PVA and PVP at a rate of 10%W for each polymer and adding various medicinal substances, such as diclofenac de ethylamine and gentamicin, in concentrations of 5%w each. The morphological structure of the produced samples was further studied using a scanning electron microscope (SEM) and X-ray diffraction (XRD) before they were turned into a medical adhesive and tested directly on a human hand. This approach has already proven to be effective in delivering the medicine to the affected area without the use of any intermediaries. It is relatively simple to use, safe for medical usage, and inexpensive due to the lack of expensive industrial apparatus required for production.