Expressions of NF-B and TFF3 in gastric cancer and its clinical significance

Abstract

Objective To study the expressions and correlation of nuclear factor kappa B （ NF-B） p65 and trefoil factor family-3（TFF3） in gastric cancer,in order to evaluate the roles of NF-Bp65 and TFF3 in the occurrence and development of gastric cancer,and their correlation with Helicobacter pylori （Hp） infection.Methods The expressions of NF-Bp65 and TFF3 were detected by immunohistochemistey in 30 normal gastric mucosa specimens ,32 dysplasia specimens and 70 gastric cancer specimens .At the same time,the infection of Hp was detected .Results In normal gastric mucosa ,dysplasia and gastric cancer ,the expression of NF-Bp65 had a increasing tendency （ compared with the normal gastric mucosa group ,χ^2 =18.632,44.291,all P〈0.01）.The expression of NF-Bp65 in gastric cancer group was higher than that in dysplasia group （χ^2 =5.205,P〈0.05）.The expression of TFF3 in three groups also had a increasing tendency （compared with the normal gastric mucosa group ,χ2 =16.944,22.917,all P 〈0.01）.The expression of TFF3 in gastric cancer group was higher than dysplasia group ,but there was no significant difference between the two groups （χ^2 =0.162,P〉0.05）.In dysplasia group,the expressions of TFF3 and NF-κBp65 in Hp positive patients were significantly higher than those in Hp negative patients （P〈0.01 or P〈0.05）.There was significantly positive correlation between expression of NF-Bp65 and TFF3 in gastric cancer group （ r=0.350,P=0.003）.Conclusion High expressions of NF-Bp65 and TFF3 may be involved in an early event of gastric cancer . NF-Bp65 expression is positively correlated with the abnormal expression of TFF 3,both of which may be involved in the development and progression of gastric cancer . Key words: Stomach neoplasms; Transcription factors