Abstract
Objective To research the expression of VEGF and it's influence to prognosis to breast cancer. Methods A retrospective analysis of the breast cancer tissue was examined immunohistochemically for VEGF and PCNA,and the data were analysed by SPSS statistic software according to clinical material . Results The positive expression of VEGF was 33/58.It was significantly higher VEGF expressing in higher histological grade and higher PCNA expessing group.However accompanied with poor prognosis.Cox proportional hazard model indicated that the positive expression of VEGF correlated positively with decreased survial(risk ratio=3.37, P =0.02). Conclusion The expression of VEGF had a significantly influence to prognosis of breast cancer,and it was a independent risk factor.
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