Abstract
Objective To explore the expression of VEGF and PGC-1α in breast carcinoma and its relationship to the tumor proliferation,infiltration and rmetastasis. Methods Immunohistochemistry and RT-PCR were used to examine the expression of VEGF, mtDNA and PGC-1α in 26 infitrating ductal breast carcinoma examples and 9 normal breast tissues respectively. Results The expression of VEGF protein and mRNA in the breast carcinoma was obviously higher than that in the normal tissues, but the mRNA expression of mtDNA and PGC-1α was higher in normal tissues. Conclusion The expression of VEGF up-regulates and PGC-1α down-regulates in the breast cancer tissue. Lower level of PGC-1α may play a role in the breast tumor cells proliferation, infiltration and metastasis. Key words: Breast neoplasm; Vascularendothelial growth factor; Peroxisome proliferator activated receptor gamma coactivator 1α
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.