Abstract
Objective To investigate Expression of thymidylate synthase (TS) in rectal cancer and its clinical significance. Methods Expression of TS was observed in 48 cases of rectal cancer (RC) tissues using immunohistochemical staining. Kaplan-Meier survival analysis was used to analyze the correlation of the expression of TS with the clinicopathologic parameters and prognosis of RC patients. Multiple COX proportional hazards model analysis was used to analyze the prognostic factors. Results The expression level of TS in RC tissues was higher than normal and RC sideward tissues, and in lower degree of tumor differentiation than in high degree, at early stage cases was higher than at advanced case. The expression level of TS in the cases with recrudescence in 2-year was high than in the cases without recrudescence in 2-year (P<0.05). Multiple analysis showed that TS expression was independent prognostic factors for RC. Conclusion The expression of TS is a significant prognostic factors for RC, and can be regarded as a index for estimating the malignant degree of RC and resistant 5-FU. Key words: Rectal cancer; Thymidylate synthase; Immunohistochemistry
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