Abstract
Background The CSF system, including the choroid plexus, is an important route for removing the A-Beta peptides that, in high concentrations, injure neurons. Central retention of A-Beta peptides occurs when the blood-CSF and bloodbrain barriers suffer deficits in aging and disease. LRP-1, a transporter, which actively removes A-Beta from extracellular fluid, undergoes expression changes in senescence, which is a risk factor for NPH and AD. We hypothesize that LRP-1 activity in the 'barriers' is essential for the wellbeing of the brain's interstitial and cerebrospinal fluids. This study has assessed the expression of LRP-1 in the choroid plexus and cerebral capillaries of aging rats in order to elucidate the state of this A-Beta clearance transporter in senescence. Faulty A-Beta disposal from the CNS may predispose to NPH and the reduced CSF turnover rate in AD.
Highlights
The CSF system, including the choroid plexus, is an important route for removing the A-Beta peptides that, in high concentrations, injure neurons
This study has assessed the expression of LRP-1 in the choroid plexus and cerebral capillaries of aging rats in order to elucidate the state of this A-Beta clearance transporter in senescence
LRP-1 by IHC assessment was expressed extensively in the choroid plexus epithelium of healthy young adults; expression of this A-Beta transporter was sustained even in the oldest animals. This was confirmed by RT-PCR, which showed mRNA for LRP-1 in the choroidal epithelium at all ages, with enhancement of the transcript in the oldest B-N/F animals
Summary
Expression of the beta-amyloid transporter, LRP-1, in aging choroid plexus: implications for the CSF-brain system in NPH and Alzheimer's disease. Conrad Johanson*, Stephanie Flaherty, Arthur Messier, John Duncan III and Gerald Silverberg. Of Clinical Neurosciences, Brown Medical School, Providence, RI 02903 USA. 50th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Meeting abstracts – A single PDF containing all abstracts in this supplement is available here.
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