Expression of signal transducer and activator of transcription 3 and glioma-associated oncogene 1 and clinical significance in colorectal carcinoma

Abstract

Objective To explore the expression of signal transducer and activator of transcription 3(STAT3),and glioma-associated oncogene 1(Gli1)and the clinical significance in colorectal carcinoma. Methods Ninety-nine cases of colorectal carcinoma tissues and non-cancerous adjacent colorectal tissues were obtained for detection of the expression of STAT3 and Gli1 by immunohistochemistry.The relationship between the expression of STAT3 and Gli1 in colorectal carcinoma tissues and clinicopathologic features were analyzed. Results The expression rate of STAT3 and Gli1 in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (60. 87% vs.11. 59%, and 75. 36% vs.37. 68%,P<0. 01).The expression of STAT3 was related to histology grade, serosa invasion, TNM stage and lymph node metastasis of colorectal carcinoma (P<0. 05).There was a close relationship in colorectal carcinoma between the expression of Gli1 and histology grade, TNM stage and lymph node metastasis(P< 0. 05). Conclusion Simultaneous detection of STAT3 and Gli1 might be helpful for evaluating the malignance and predicting the metastatic potential of colorectal carcinoma. Key words: Signal transducer and activator of transcription 3; Glioma-associated oncogene 1; Colorectal carcinoma