Abstract
Aim To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson's test. Results Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P < 0.05). The ROC curve of diagnosis of acute cerebral infarction showed that the area under curve of miR-210 was 0.836, that of miR-137 was 0.843, and that of miR-153 was 0.842. The 1-year survival rate was 71.05%. The 1-year survival of the low-expression group of miR-210 and miR-137 was significantly lower than that of the high-expression group, while the 1-year survival of the low-expression group of miR-153 was significantly higher than that of the high-expression group (all P < 0.05). The ROC curve for predicting death showed that the area under curve of miR-210 was 0.786, that of miR-137 was 0.824, and that of miR-153 was 0.858. Pearson's correlation analysis showed that the expression of miR-210 was positively correlated with that of miR-137, while miR-137 was negatively correlated with that of miR-153 and miR-210 was negatively correlated with that of miR-153. Conclusion miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.
Highlights
Cerebral infarction is a kind of brain injury caused by obstruction of blood supply in the brain
Clinical Data of Patients. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were selected as the observation group in this study, including 45 males and 31 females, with an average age of 57:0 ± 6:4 years
By comparing the expression of miR210, miR-137, and miR-153, we found that miR-210 in the observation group (1:18 ± 0:26) was significantly lower than that in the control group (1:64 ± 0:48) (P < 0:05), and miR137 in the observation group (0:84 ± 0:24) was significantly lower than that in the control group (1:26 ± 0:31) (P < 0:05 ), but miR-153 in the observation group (1:52 ± 0:45) was significantly higher than that in the control group (0:96 ± 0:36) (P < 0:05)
Summary
Cerebral infarction is a kind of brain injury caused by obstruction of blood supply in the brain. The incidence and mortality of cerebral infarction are much higher than those of other brain injury diseases [1, 2]. Most of acute stroke is acute cerebral infarction, which has become the main cause of global disability events [3, 4]. The number of cerebral infarction patients worldwide was 33 million in 2010, and it would increase to 77 million by 2030 according to epidemiological speculation [6]. We need some indicators to diagnose the disease and predict the prognosis, so that medical staff can carry out targeted and effective treatment according to the predicted situation
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