Abstract
Objective To investigate the distribution of ApoE gene polymorphism in patients with acute cerebral infarction (ACI) and to explore the its correlation with the expression of lipoprotein-associated phospholipase A2 (Lp-PLA2). Methods A case-control study was conducted in 112 ACI inpatients that visited the Department of Neurology, the Third People′s Hospital of Liaocheng from July 2015 to June 2017 and 59 age-matched healthy subjects were included as control. Nucleic acid probe hybridization chips were used to detect the genotypes of ApoE and serum Lp-PLA2 was measured by the up-converting luminescence technique. Results The allele frequencies of ApoE E2, E3 and E4 in the control group were 21.19%, 73.73% and 5.08%, respectively. The genotype frequency of ApoE conforms to the balance of Hardy-Weinberg. The frequency of E2 allele in ACI group (6.25%) was significantly lower than that in control group (21.19%) (P 0.05), while there were significant differences among the other groups (P<0.01). The AUC value of serum Lp-PLA2 was 0.790 (95%CI 71.9-86.1). The critical point of clinical diagnosis is 123.01ng/ml,the sensitivity was 67.8%, the specificity was 69.6%, and the expression level of Lp-PLA2 was significant (P<0.01) for judging the occurrence of ACI. Logistic regression analysis showed that Lp-PLA2 and ApoE E4 alleles were both risk factors for the diagnosis and treatment of ACI. Conclusion The ApoE E4 allele is a risk factor for acute cerebral infarction and Lp-PLA2 expression is closely related with ACI patients. The detection of ApoE genotype and serum Lp-PLA2 is of certain clinical significance in the diagnosis of ACI. Key words: Acute cerebral infarction; Apolipoprotein E; Gene polymorphism; Allele; Lipoprotein-associated phospholipase A2
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