Abstract
Objective: To explore the value of integrin-linked kinase (ILK) in the diagnosis of gastric cancer, its mechanism of action in the pathogenesis and its influence on tumor metastasis. Methods: Collect 100 cases of gastric cancer diagnosed pathologically, detect the positive expression of ILK, and analyze its biological characteristics. Results: The positive rate of ILK in gastric cancer tissue (57.0%) is significantly higher than that in the control group (12%), and the positive rate of ILK gradually increased with the progress of superficial gastritis, chronic atrophic gastritis with atypical hyperplasia and gastric cancer. The differences between the four groups are statistically significant. There is a significant difference in the positive rate of ILK among well-differentiated, moderately-differentiated, poorly-differentiated and undifferentiated adenocarcinomas (P<0.001). The positive rate (25%) of ILK in the uninvaded serosal layer (T1+T2) is significantly lower than the positive rate (75.0%) in the invaded serosal layer (T3+T4). There is a significant difference in the positive rate of ILK in stage I, II, III and IV (P<0.001). In the localized type (I+II), the positive rate of ILK (24.39%) is significantly lower than that of the invasive type (III+IV) (79.66%). The positive rate of ILK in patients without lymph node metastasis (30.23%) is significantly lower than that of patients with lymph node metastasis (77.19%). Conclusion: The positive rate of ILK in gastric cancer tissue is significantly higher than that in adjacent tissues. The higher the positive rate, the worse the prognosis. ILK is an independent risk factor affecting the prognosis of patients.
Highlights
Gastric cancer (GC) is one of the most common gastrointestinal malignant tumors in the clinic
integrin-linked kinase (ILK) is rarely expressed in normal human tissues, but it is highly expressed in neurogenic tumors, lung cancer, melanoma, ovarian cancer, prostate cancer, gastric cancer, and colon cancer, and its expression level gradually increases with the increase of tumor pathological grade
A total of 100 patients with primary gastric cancer diagnosed for the first time from the Department of Gastrointestinal Surgery, Cangzhou People's Hospital, Department of General Surgery, Cangzhou Central Hospital, and Department of External Medicine, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital Histopathologically from January 2016 to October 2017, all patients with gastric cancer do not undergo chemotherapy or radiotherapy before surgery. 100 cases of gastric cancer tissues removed by surgery. 40 cases of normal gastric mucosa (5.0 cm away from the edge of the tumor) tissues, 40 cases of superficial gastritis with gastroscope biopsy, and 20 cases of chronic atrophic gastritis with dysplasia are placed in 10% of neutral formalin buffer that fixed for 24h, and embedded in paraffin
Summary
Gastric cancer (GC) is one of the most common gastrointestinal malignant tumors in the clinic. Researches have shown that integrin-linked kinase (ILK) is an important effector in the signal transduction pathway of integrin and growth factor receptors. It has multiple biological functions and participates in cell proliferation, differentiation, growth, the regulation of adhesion, migration, infiltration and tumor angiogenesis. ILK is rarely expressed in normal human tissues, but it is highly expressed in neurogenic tumors, lung cancer, melanoma, ovarian cancer, prostate cancer, gastric cancer, and colon cancer, and its expression level gradually increases with the increase of tumor pathological grade. The immunohistochemical method (SP method) is used for detecting the expression of ILK in specimens of gastric cancer, normal gastric mucosa and adjacent tissues, analyzing the relationship and correlation with the clinicopathological characteristics, invasion, and metastasis of gastric cancer, and exploring the diagnostic value of gastric cancer and its role in the pathogenesis of gastric cancer and its impact on tumor metastasis, which provides theoretical basis for early diagnosis, prognosis and targeted therapy of gastric cancer
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