Abstract
Purpose: Discuss the diagnosis value and action mechanism of S100P for gastric cancer and the influence of S100P in tumor metastasis. Method: Collect 100 cases of gastric cancer tissues diagnosed as per histopathology by our hospital, apply immunohistochemistry method, test the positive expression condition of S100P protein, compare with 100 cases of control tissue specimens, and analyze the relationship between S100 protein expression condition in gastric cancer tissue and clinical pathology. Result: the positive rate (51.0%) of S100P in gastric cancer tissue is significantly lower than chronic atrophic gastritis with atypical hyperplasia, superficial gastritis and normal gastric mucosa (P<0.001 or P<0.05), while the difference between gastric cancer group and group of chronic atrophic gastritis with atypical hyperplasia has no statistic significance (P>0.05). The difference of positive rate of S100P in gastric cancer tissue with gender, age, tumor size, tumor position and Lauren typing has no statistic significance. In well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma and adenocarcinoma anaplastic, the positive rate (80.56%) of S100P of the three groups has significant difference (χ<sup>2</sup>=13.912, P=0.001). The positive rate of S100P which doesn’t invade serosa is significantly higher than the positive rate (34.38%, χ<sup>2</sup>=19.662, P<0.001) of S100P invading serosa and invading beyond the serosa, and the difference of positive rate of S100P of Phase I, Phase II, Phase III and Phase IV also has statistic difference (χ<sup>2</sup>=13.347, P=0.004), the positive rate (73.17%) of localized S100P protein is significantly higher than the positive rate (35.59%, χ<sup>2</sup>=13.669, P<0.001) of invasive type; the positive rate (74.42%) of S100P without lymph node metastasis is significantly higher than the positive rate (33.33%, χ<sup>2</sup>=15.020, P<0.001) with lymph node metastasis. Conclusion: the positive rate of S100P protein in gastric cancer tissue is significantly lower than the para-carcinoma tissue; the lower the differentiation degree is, the deeper the invasion is; the patients who have later TNM staging and Borrmanntyping, and lymph node metastasis have lower positive rate of S100P protein, which indicates that the low expression of S100P protein participates in the occurrence, development, invasion and metastasis of gastric cancer, and is an independent dangerous factor affecting the patients’ prognosis.
Highlights
Gastric cancer (GC) is one of the most common cancers in the world, as well as one of the common malignant tumors of digestive tract
As gastric cancer has the features of concealment, high missed diagnosis rate, high reoccurrence rate, and death rate, etc., most of the gastric cancer patients have been at the progressive stage when they are diagnosed, which causes the low rate for having radical resection, and high occurrence rate for post-surgery reoccurrence and metastasis, with the median survival time as only 3 to 24 months, and the 5-year survival rate as only about 40%[3]
The positive rate (51.0%, 51/100) of S100P in gastric cancer tissue is significantly lower than the control group (83%, 83/100), and the difference has statistic significance (χ2=28.86, P
Summary
Gastric cancer (GC) is one of the most common cancers in the world, as well as one of the common malignant tumors of digestive tract. Researches discover that S100P is a new tumor marker, has abnormal expression in the tumor cells of prostatic cancer, transitional cell carcinoma of bladder, non-small cell lung cancer, etc., participates in the abnormal hyperplasia and malignant transformation, promotes the movement of tumor cells, enhances the invasion capability of tumors, plays an important role in the occurrence and development of tumors, and correlates to the clinical staging, metastasis, prognosis and drug sensitivity of the tumor. This research takes 100 cases of primary gastric cancer tissuesdiagnosed by histopathology as the research object, applies immunohistochemistry dyeing method, tests the expression of S100P protein in gastric cancer, normal gastric mucosa and paracancerous control tissue specimens, analyzes the relationship of the two with clinical pathology, invasion, and metastasis of gastric cancer and their correlation, and discusses its role in the occurrence and development process of gastric cancer, and its influences in gastric cancer, and provides theoretic basis for early diagnosis, prognosis evaluation and targeted therapy
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