Expression of chromobox protein homolog 3 and p53 proteins in hepatocellular carcinoma and their correlation with pathological features

Abstract

Objective To investigate the expression of chromobox protein homolog 3 (CBX3) and p53 protein in hepatocellular carcinoma and their correlation. Methods Sixty patients with liver cancer and their corresponding adjacent tissues were selected. Immunofluorescence and Western blotting were used to detect the expression of CBX3 and p53 protein in hepatocarcinoma tissues and adjacent tissues, and to analyze their correlation with tumor size, TNM stage, tumor differentiation, vascular thrombosis and lymph node metastasis. Sex. The χ2 test of the paired data analyzed the correlation between the two proteins. Results The positive expression rates of CBX3 protein and p53 protein in liver cancer tissues were 76.7% and 71.7%, respectively. CBX3 protein expression and tumor size (χ2=5.293, P<0.05), vascular tumor thrombus (χ2=5.671, P<0.05), lymph node metastasis (χ2=4.543, P<0.05), TNM staging (χ2=6.229, P<0.05) and The degree of tumor differentiation (χ2=10.221, P<0.01) was significantly correlated. p53 protein expression and tumor size (χ2=5.844, P<0.05), vascular tumor thrombus (χ2=4.966, P<0.05), lymph node metastasis (χ2=6.570, P<0.05), TNM staging (χ2=5.629, P<0.05), The degree of tumor differentiation (χ2=13.611, P<0.01) was significantly correlated. The expression levels of CBX3 and p53 protein were 10.09-fold and 7.35-fold, respectively, and they were positively correlated (r=0.359, P<0.05). Conclusion The expression of CBX3 and p53 protein is up-regulated in hepatocarcinoma tissues, which is significantly correlated with tumor size, TNM stage, tumor tissue differentiation, vascular thrombosis and lymph node metastasis. CBX3 protein was positively correlated with p53 protein positive expression. Key words: Chromobox protein homolog 3; P53 protein; Liver cancer